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Zagouri F, Bago-Horvath Z, Rossler F et al. High MET expression is an adverse prognostic factor in patients with triple-negative breast cancer. British Journal of Cancer. Early online publication February 19, 2013.

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MET Protein Linked with Prognosis in Triple-Negative Breast Cancer
Date of publication: February 19, 2013

According to a study published in the British Journal of Cancer, higher tumor levels of a protein known as MET may be linked with worse outcomes among women with triple-negative breast cancer. Drugs that target MET are currently being investigated for the treatment of several types of cancer, including triple-negative breast cancer.

The MET protein is part of a biological pathway that functions abnormally in many types of cancer. To explore whether tumor levels of MET affect the prognosis of triple-negative breast cancer, researchers in Vienna evaluated samples of tumor tissue from 170 women.

Just over half of the tumors (52%) had high levels of MET. After accounting for other factors that affect prognosis, high levels of MET were linked with a more than three-fold increase in risk of cancer recurrence.

These results suggest that MET-targeted therapies may provide a benefit in triple-negative breast cancer. Clinical trials to evaluate promising drugs are currently underway.

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