Wu Y, Sarkissyan M, Eishimali Y, Vadgama JV. Triple-negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN. PLOS One. 2013;8(10):e78259.
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Study Explores Breast Cancer Characteristics in African-American and Hispanic/Latina Women
Date of publication: October 22, 2013
In a study of African-American and Hispanic/Latina women with breast cancer, there was a high prevalence of triple-negative breast cancer. These results were published in PLOS One.
Studies have previously reported that African-American women have high rates of triple-negative breast cancer, but the specific biologic characteristics of these cancers are still being explored.
To provide additional information about the characteristics of breast cancers in African-American and Hispanic/Latina women, researchers collected information from 318 women from South Los Angeles who were participating in an ongoing study.
Additional research into the biologic underpinnings of certain types of breast cancer may suggest new ways to treat these cancers.
- Hormone receptor-positive/HER2-negative breast cancer was the most common type of breast cancer, accounting for 49% of breast cancers in both African-American and Hispanic/Latina women.
- Triple-negative breast cancer was the second most common type of breast cancer, and occurred in 35% of the African-American women and 28% of the Hispanic/Latina women.
- The researchers evaluated several biological characteristics of the breast cancers. One of these—loss of a protein known as PTEN—was common in triple-negative breast cancers, and was linked with worse survival in African-American women. Loss of PTEN did not appear to affect survival in Hispanic/Latina women.
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