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Triple Negative Breast Cancer
Fact Sheet
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- Triple negative breast cancer (TNBC) is one of many forms of breast cancer.
- Forms of breast cancer are generally diagnosed based on the presence or absence of three "receptors" known to fuel most breast cancer tumors: estrogen, progesterone and HER2-neu.
- A diagnosis of TNBC means that the tumor in question is estrogen-receptor negative, progesterone-receptor negative and Her2-negative. In other words, triple negative breast cancer tumors do not exhibit any of the three known receptors.
- Receptor- targeting therapies have fueled tremendous recent advances in the fight against breast cancer. Unfortunately, there is no such targeted therapy for triple negative breast cancer.
- TNBC tends to be more aggressive, more likely to recur, and more difficult to treat because there is no targeted treatment.
- TNBC disproportionately strikes younger women, women of African, Latina or Caribbean descent, and those with BRCA1 mutations.
- Approximately every half hour, another woman in the US is diagnosed with triple negative breast cancer.
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White, not Hispanic |
Black |
Hispanic Origin |
Asian/Pacific Islands |
Native American |
TOTAL |
Total US Population
(2010 Census) |
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|
|
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308,745,538 |
| % by Race |
63.7% |
12.6% |
16.3% |
5.0% |
0.9% |
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| % Female |
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50.8% |
| US Female Population |
99,908,821 |
19,762,184 |
25,565,366 |
7,842,137 |
1,411,585 |
156,842,733 |
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Invasive BC Rate per 100K
(ACS Cancer Facts and Figures 2012)
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122.3 |
116.1 |
92.3 |
84.9 |
89.2 |
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| |
| Est Annual Invasive BC Cases |
122,188 |
22,944 |
23,597 |
6,658 |
1,259 |
168,729 |
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Est Triple Negative Rate
(Oncology 7/12/11)
(Note: Asian and Native American TNBC rate is estimated at average overall rate of 15%)
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11% |
25% |
17% |
15% |
15% |
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| Est Triple Negative Cases |
13,411 |
5,736 |
4,011 |
999 |
139 |
24,376 |
| % of All Invasive BC |
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14.4% |
About the Triple Negative Breast Cancer Foundation (TNBCF)
Triple Negative Breast Cancer Foundation (TNBCF) was founded in 2006 in honor of Nancy Block-Zenna, who was diagnosed at the young age of 35 with triple negative breast cancer before succumbing to the disease in 2007. In response to Nancy's diagnosis, her friends identified a dire need to create a central source of information for this dangerous and aggressive form of breast cancer, about which little was known just a short time ago. It is the Foundation's mission to raise awareness of triple negative breast cancer and to support scientists and researchers in their effort to determine the disease's definitive causes, so that effective detection, diagnosis, prevention and treatment can be pursued and achieved. TNBCF supports the triple negative breast cancer community in many ways:
- We host regular "think tanks" which are attended by the top doctors and researchers in the field, to create roadmaps for a cure for triple negative breast cancer.
- We offer research grant support to encourage the launch of projects aimed at finding targeted treatments for triple negative disease.
- We co-sponsor a $6.4 million Promise Grant with Susan G. Komen for the Cure, which is aimed at finding targeted therapy for triple negative disease.
- We offer a financial assistance program to help women with triple negative breast cancer afford transportation, child care and other expenses associated with their treatment.
- We continuously expand our website, www.tnbcfoundation.org, and offer an ever-growing resources section and up-to-the-minute information about the disease.
- We host online forums which offer the TNBC community a central place to go for support and information about the disease.
- We offer a TNBC Helpline, where patients can call and speak with oncology social workers specifically trained to address the needs of the triple negative breast cancer community.
- We constantly work to educate patients about triple negative breast cancer through teleconferences and webinars, and with printed and online materials that have proven to be essential resources for newly diagnosed patients.
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